Inflammation is an essential part of the body’s defense and repair system, but when inflammatory activity becomes chronic and low-grade, it can contribute to biological aging and age-related disease. This long-term inflammatory state is often described as inflammaging and is closely connected with immune function, oxidative stress, metabolic health, tissue repair, and systemic resilience.
This curated list focuses on research that explains how chronic inflammation, immune aging, oxidative stress, and cellular stress responses interact over time. These papers support a systems-level view of longevity, where healthy aging depends not only on individual cells, but on the body’s ability to regulate immune and inflammatory balance.
These papers support one part of the broader High Coast Longevity framework described in Longevity Science Today.
Inflammation & Systemic Health Publications
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Authors: Claudio Franceschi, Paolo Garagnani, Paolo Parini, Cristina Giuliani, Aurelia Santoro
Publication: Nature Reviews Endocrinology, 2018
Type: Review
Tags: inflammaging, inflammation, immune metabolism, aging, age-related disease
This review explains inflammaging as a chronic, sterile, low-grade inflammatory state that develops during aging and contributes to age-related disease. It highlights how immune activation, metabolic stress, gut microbiota, cellular debris, and tissue-level damage can interact to sustain inflammation over time. The paper is important for understanding aging as a systemic process involving both immune and metabolic regulation.
The Role of Immune Cells in Oxi-Inflamm-Aging
Authors: Irene Martínez de Toda, Noemi Ceprián, Estefanía Díaz-Del Cerro, Mónica De la Fuente
Publication: Cells, 2021
Type: Review
Tags: immune aging, oxidative stress, inflammatory stress, biological age, immune cells
This review describes how immune cells participate in the interaction between oxidative stress and chronic inflammation during aging. It explains how age-related changes in immune function can both reflect and drive biological aging, partly through increased oxidative and inflammatory stress. The paper also discusses how lifestyle factors such as nutrition, exercise, and social environment may influence immune function and the rate of aging.
