Nature Portfolio
Nature and the Nature Portfolio are among the most respected scientific publishing platforms in the world, covering major advances across biology, medicine, genetics, molecular science, and health research. In aging and longevity science, Nature publications often highlight research that deepens our understanding of biological age, cellular senescence, epigenetic regulation, mitochondrial function, and measurable biomarkers of aging.
This curated list focuses on recent Nature Portfolio publications connected to the High Coast Longevity framework, including biological age measurement, senolytics, omics-based biomarkers, and conserved molecular patterns of aging. The goal is to make high-impact research easier to explore and to connect leading scientific findings with the biological systems that influence long-term health, resilience, and longevity.
For a broader interpretation of how these publications fit into modern longevity science, read Longevity Science Today.
Curated Recent Publications
Cellular senescence and senolytics: the path to the clinic
Authors: Selim Chaib, Tamar Tchkonia, James L. Kirkland
Publication: Nature Medicine, 2022
Cellular senescence is a biological state in which damaged or stressed cells stop dividing but remain metabolically active. This review describes how persistent senescent cells can contribute to tissue dysfunction through inflammatory signaling, and how senolytic therapies are being developed to selectively target these cells. The paper is important for understanding cellular aging, inflammation, and emerging therapeutic strategies aimed at age-related disease.
Measuring biological age using omics data
Authors: Jarod Rutledge, Hamilton Oh, Tony Wyss-Coray
Publication: Nature Reviews Genetics, 2022
This review explains how modern omics technologies—such as epigenomics, transcriptomics, proteomics, and metabolomics—can be used to measure biological aging at the molecular level. The paper highlights how aging clocks and biomarker models may help distinguish biological age from chronological age, making it highly relevant to the future of longevity assessment and personalized prevention.
Universal DNA methylation age across mammalian tissues
Authors: A. T. Lu et al.
Publication: Nature Aging, 2023
This study developed DNA methylation clocks across a wide range of mammalian species and tissues. The findings suggest that aging leaves measurable molecular signatures that are partly conserved across mammals. This work is important for biological age research and supports the idea that aging can be studied through shared molecular patterns across species.
